Stool microbiota show greater linkages with plasma metabolites compared to salivary microbiota in a multinational cirrhosis cohort.
Isobel Jane CoxMarcela Peña RodríguezAndrew FaganMayra V Rojas-LaraAdrien Le GuennecFatima Rodriguez-AlvarezSara McGeorgeIvonne Escalona-NandezAldo TorreJasmohan Singh BajajPublished in: Liver international : official journal of the International Association for the Study of the Liver (2022)
Stool microbiota were more extensively linked with systemic metabolites than were saliva microbiota, irrespective of cirrhosis severity and country. These changes were more prominent in decompensated cirrhosis and were centred around plasma lactate, which might reflect the interaction of diet and lactulose therapy.