Minocycline suppresses lipogenesis via inhibition of p300 histone acetyltransferase activity in human SZ95 sebocytes.

H S ShinC C ZouboulisM K KimD H LeeJin Ho Chung

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

Our findings revealed a novel sebum-regulating effect of minocycline. Moreover, as p300 HAT is a key epigenetic regulator of sebaceous lipogenesis, its inhibitors could be used for the treatment of acne vulgaris.

Keyphrases

dna methylation
endothelial cells
gene expression
signaling pathway
transcription factor
single cell
type diabetes
combination therapy
metabolic syndrome
insulin resistance
replacement therapy