Effects of Angiotensin-Converting Enzyme Inhibition on Circulating Endothelial Progenitor Cells in Patients with Acute Ischemic Stroke.
Monika Gołąb-JanowskaEdyta PaczkowskaBogusław MachalińskiDariusz KotlęgaAgnieszka MellerKrzysztof SafranowMichał MajPrzemysław NowackiPublished in: Stem cells international (2018)
An increased number of circulating stem cells and early EPCs were not observed in stroke patients chronically treated with ACEI. In patients chronically treated with ACEI, a significant correlation was observed between decreased neurological deficit and higher levels of CD133+ cells; this could be due to the positive influence of these cells on the regeneration of the endothelium and improved circulation in the ischemic penumbra.
Keyphrases
- stem cells
- acute ischemic stroke
- induced apoptosis
- angiotensin converting enzyme
- newly diagnosed
- cell cycle arrest
- end stage renal disease
- angiotensin ii
- ejection fraction
- chronic kidney disease
- endoplasmic reticulum stress
- nitric oxide
- endothelial cells
- prognostic factors
- signaling pathway
- peritoneal dialysis
- mesenchymal stem cells
- pi k akt
- cerebral ischemia