Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity.
Alexandra BorodovskyChristine M BarbonYanjun WangMinwei YeLaura PrickettDinesh ChandraJoseph ShawNanhua DengKris SachsenmeierJames D ClarkeBolan LinghuGiles A BrownJames BrownMiles CongreveRobert Ky ChengAndrew S DoreEdward HurrellWenlin ShaoRichard WoessnerCorinne ReimerLisa DrewStephen FawellAlwin G SchullerDeanna A MelePublished in: Journal for immunotherapy of cancer (2021)
We provide evidence implicating suppression of adaptive and innate immunity by adenosine as a mechanism for immune evasion by tumors. Inhibition of adenosine signaling through selective small molecule inhibition of A2AR using AZD4635 restores T cell function via an internal mechanism as well as tumor antigen cross-presentation by CD103+ DCs resulting in antitumor immunity.