Omicron variant-specific serological imprinting following BA.1 or BA.4/5 bivalent vaccination and previous SARS-CoV-2 infection: A cohort study.
Eva A M BaerendsJoanne ReekieSigne R AndreasenNina B StærkeDorthe RabenHenrik NielsenKristine T PetersenIsik S JohansenSusan O LindvigLone W MadsenLothar WieseMette B IversenThomas Lars BenfieldKasper Karmark IversenFredrikke D LarsenSidsel D AndersenAnna K JuhlLisa L DietzAstrid K HvidtSisse R OstrowskiTyra G KrauseLars ØstergaardOle S SøgaardJens Dilling LundgrenMartin TolstrupPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)
Vaccination and previous infection leave a clear serological imprint that is focused on the variant-specific antigen. Importantly, both bivalent vaccines induce high levels of omicron variant-specific antibodies, suggesting broad cross-protection of omicron variants.