Adjunctive Intravenous Argatroban or Eptifibatide for Ischemic Stroke.
Opeolu AdeoyeJoseph BroderickColin P DerdeynJames C GrottaWilliam BarsanOladi BenthoScott BerryMauricio ConchaIris DavisStacie DemelJordan ElmNina GentileTodd GravesMelissa HoffmanJosephine HuangJames InglesScott JanisAdam S JasnePooja KhatriSteven R LevineAniel MajjhooPeter PanagosArthur PancioliStephanie PizzellaTamra RanasingheNoor SabaghaSanjeev SivakumarChristopher StreibAchala VagalAlastair WilsonMax WintermarkAlbert J YooAndrew D BarretoPublished in: The New England journal of medicine (2024)
In patients with acute ischemic stroke treated with intravenous thrombolysis within 3 hours after symptom onset, adjunctive treatment with intravenous argatroban or eptifibatide did not reduce poststroke disability and was associated with increased mortality. (Funded by the National Institute of Neurological Disorders and Stroke; MOST ClinicalTrials.gov number, NCT03735979.).