Intestinal Epithelial Responses to IL-17 in Adult Stem Cell-derived Human Intestinal Organoids.
Chansu LeeJoo Hye SongYeo-Eun ChaDong Kyung ChangYoung-Ho KimSung Noh HongPublished in: Journal of Crohn's & colitis (2022)
IL-17 induces the pyroptosis of ISCs and enterocytes, as well as mucin secretion of goblet cells and IgA transcytosis of epithelial cells. Paradoxical gastrointestinal effects of IL-17 neutralising antibodies may be associated with inhibition of mucin secretion and IgA transcytosis. The inhibition of pyroptosis using CASP1 inhibitors prevents IL-17 induced cytotoxicity without compromising its beneficial effects.