Investigation of anti-cancer and migrastatic properties of novel curcumin derivatives on breast and ovarian cancer cell lines.

Jinsha KorothSnehal NirgudeShweta TiwariVidya GopalakrishnanRaghunandan MahadevaSujeet KumarSubhas S KarkiBibha Choudhary

Published in: BMC complementary and alternative medicine (2019)

Both ST03 and ST08 exhibit anti-cancer activity at nanomolar concentration. They induce cell death by activating the intrinsic pathway of apoptosis. Also, they inhibit migration of the cancer cells by inhibiting MMP1 in breast cancer cells.

Keyphrases

cell death
cell cycle arrest
breast cancer cells
signaling pathway
oxidative stress
endoplasmic reticulum stress
pi k akt