An inhibitory single-domain antibody against protein Z-dependent protease inhibitor promotes thrombin generation in hemophilia A and FXI deficiency.

Claire AuditeauTung Son NguyenFloriane DevauxFrancois SallerIvan PeyronAdeline BlandinieresChristelle ReperantSadyo DarameCecile DenisPeter J LentingDelphine BorgelElsa P Bianchini

Published in: Thrombosis and haemostasis (2024)

ZPI-sdAb2 is the first specific, direct ZPI inhibitor found to exhibit procoagulant activity in plasma. This sdAb might have potential as a treatment for hemophilia or other bleeding disorders.

Keyphrases

atrial fibrillation
amino acid
binding protein
human health
small molecule
climate change