Sex-Specific Effects of Early-Life Iron Deficiency and Prenatal Choline Treatment on Adult Rat Hippocampal Transcriptome.

Shirelle X LiuTenille K FredricksonNatalia Calixto MancipeMichael K GeorgieffPhu V Tran

Published in: Nutrients (2023)

This study provided unbiased global assessments of gene expression regulated by iron and choline in a sex-specific manner, with greater effects in female than male rats. Our new findings highlight potential sex-specific gene networks regulated by iron and choline for further investigation.

Keyphrases

iron deficiency
early life
gene expression
genome wide
dna methylation
copy number
single cell
oxidative stress
human health
young adults
genome wide identification
transcription factor
temporal lobe epilepsy