In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET.
Stefanie PektorLina HilscherKerstin C WalzerIsabelle MiedererNicole BausbacherCarmen LoquaiMathias SchreckenbergerUgur SahinMustafa DikenMatthias MiedererPublished in: EJNMMI research (2018)
Our preclinical results show rapid and transient vaccination-induced increase of FDG uptake within the spleen reflecting immune activation preceding T cell proliferation. FDG-PET/CT in patients is also capable to image this immune activation resulting in a new potential application of FDG-PET/CT to image immune processes in new immunological therapies.
Keyphrases
- pet ct
- positron emission tomography
- cell proliferation
- immune response
- pet imaging
- end stage renal disease
- deep learning
- ejection fraction
- chronic kidney disease
- high resolution
- newly diagnosed
- computed tomography
- prognostic factors
- papillary thyroid
- high glucose
- risk assessment
- cell cycle
- squamous cell carcinoma
- drug induced
- dendritic cells
- machine learning
- young adults
- oxidative stress
- inflammatory response
- pi k akt
- human health
- cerebral ischemia
- quantum dots
- brain injury
- loop mediated isothermal amplification
- fluorescence imaging