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Model-based assessment of the safety of community interventions with primaquine in sub-Saharan Africa.

Stijn W van BeekElin M SvenssonAlfred B TionoJoseph OkebeUmberto D'AlessandroBronner P GonçalvesTeun BousemaChris DrakeleyRob Ter Heine
Published in: Parasites & vectors (2021)
This study supports the feasibility of MDA with SLD-PQ in a sub-Saharan African setting by predicting small and transient reductions in hemoglobin levels. In a setting where a substantial proportion of the population had low hemoglobin concentrations, our simulations suggest treatment with SLD-PQ would result in small increases in the prevalence of anemia which would most likely be transient.
Keyphrases
  • healthcare
  • risk factors
  • chronic kidney disease
  • physical activity
  • breast cancer cells
  • molecular dynamics
  • signaling pathway
  • cell death
  • brain injury
  • cell cycle arrest
  • subarachnoid hemorrhage