Greater resistance to footshock punishment in female C57BL/6J mice responding for ethanol.
Elizabeth A SneddonKaila A FennellSachi BhatiJoshua E SettersKristen M SchuhJenelle N DeMedioBrandon J ArnoldSean C MonroeJennifer J QuinnAnna K RadkePublished in: Alcoholism, clinical and experimental research (2023)
Females continue to respond for 10% ethanol despite a 0.35 mA footshock, and this behavior is not due to differences in footshock sensitivity between males and females. These results show that female C57BL/6J mice are generally more resistant to punishment in an operant self-administration paradigm. The findings add to the literature characterizing aversion-resistant alcohol-drinking behaviors in females.