Metapangenomics reveals depth-dependent shifts in metabolic potential for the ubiquitous marine bacterial SAR324 lineage.

Dominique BoeufJohn M EppleyDaniel R MendeRex R MalmstromTanja WoykeEdward F DeLong

Published in: Microbiome (2021)

Combining pangenomic and both metagenomic and metatranscriptomic profiling revealed a striking divergence in the vertical distribution, genomic composition, metabolic potential, and predicted lifestyle strategies of geographically co-located members of the SAR324 bacterial clade. The results highlight the utility of metapangenomic approaches employed across environmental gradients, to decipher the properties and variation in function and ecological traits of specific phylogenetic clades within complex microbiomes. Video abstract.

Keyphrases

human health
single cell
risk assessment
metabolic syndrome
climate change
physical activity
genome wide
weight loss
gene expression
copy number
microbial community