Upregulated immuno-modulator PD-L1 in malignant peripheral nerve sheath tumors provides a potential biomarker and a therapeutic target.

Said C Farschtschi Lan KluweSu-Jin ParkSu-Jun OhNancy MahVictor-Felix MautnerAndreas Kurtz

Published in: Cancer immunology, immunotherapy : CII (2020)

The immuno-modulator PD-L1 is upregulated in MPNST patients and therefore may provide as a potential biomarker of malignant transformation in patients with NF1 and as a response predictor for immunotherapeutic approaches.

Keyphrases

peripheral nerve
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
signaling pathway
prognostic factors
peritoneal dialysis
oxidative stress
nuclear factor