[Underuse of SGLT2 inhibitors in clinical practice].
André J ScheenPublished in: Revue medicale suisse (2024)
SGLT2 inhibitors (gliflozins) have proven their efficacy in reducing complications due to atherosclerotic cardiovascular disease, heart failure and chronic kidney disease both in placebo-controlled clinical trials and in real-life studies versus other glucose-lowering agents (except GLP-1 analogues) in patients with type 2 diabetes. Hence, observational studies demonstrate that they are poorly used in -clinical practice, including in patients at high cardiorenal risk. -Reasons are multiple and involve physicians, patients and health care system with restricted criteria for prescription and reimbursement in many countries. Bridging the gap between scientific proves from evidence-based medicine and clinical practice represents a major health-care issue.
Keyphrases
- clinical practice
- end stage renal disease
- chronic kidney disease
- heart failure
- cardiovascular disease
- clinical trial
- healthcare
- peritoneal dialysis
- newly diagnosed
- ejection fraction
- primary care
- type diabetes
- study protocol
- double blind
- left ventricular
- atrial fibrillation
- phase ii
- open label
- patient reported outcomes
- cardiac resynchronization therapy
- cardiovascular events
- structure activity relationship