A significant effect of the killer cell immunoglobulin-like receptor ligand human leucocyte antigen-C on fibrosis progression in chronic C hepatitis with or without liver transplantation.

Stéphane BuhlerEmiliano GiostraCorinne GbameCasimir de RhamBeat MullhauptJean-François DufourPietro MajnoFrancesco NegroPierre-Yves BochudJean Villardnull null

Published in: Liver international : official journal of the International Association for the Study of the Liver (2016)

This study suggests a possible role of killer cell immunoglobulin-like receptors and their ligands in the development of liver damage. The absence of C1 and C2 ligands heterozygosity could lead to less inhibition of natural killer cells and a quicker progression to a high level of fibrosis in patients infected with hepatitis C virus, especially following liver transplantation.

Keyphrases

hepatitis c virus
natural killer cells
single cell
end stage renal disease
cell therapy
newly diagnosed
ejection fraction
endothelial cells
chronic kidney disease
oxidative stress
human immunodeficiency virus
prognostic factors
peritoneal dialysis
stem cells
mesenchymal stem cells
liver fibrosis
patient reported