Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities.

Niels Eiel SteenZillur RahmanAttila SzaboGuy Frederick Lanyon HindleyNadine ParkerWeiqiu ChengAihua LinKevin S O'ConnellMashhood A SheikhAlexey ShadrinShahram BahramiSandeep KarthikeyanEva Z HosethAnders M DalePål AukrustOlav B SmelandThor UelandOleksandr FreiSrdjan DjurovicOle A Andreassen

Published in: Schizophrenia bulletin (2023)

Our results suggest that genetic factors involved in WBC counts are associated with the risk of SCZ, indicating a role of immune mechanisms in subgroups of SCZ with potential for stratification of patients for immune targeted treatment.

Keyphrases

genome wide
end stage renal disease
ejection fraction
newly diagnosed
single cell
bipolar disorder
peripheral blood
prognostic factors
stem cells
risk assessment
dna methylation
mesenchymal stem cells
climate change
cancer therapy
bone marrow
drug delivery