Neurological autoimmunity in melanoma patients: a comparison between those exposed and non-exposed to immune checkpoint inhibitors.

Andreu VilasecaAntonio FarinaMacarena Villagrán-GarcíaAntoine PegatMarie BenaiteauNicolás Lundahl Ciano-PetersenLe-Duy DoVéronique RogemondDavid GonçalvesDimitri PsimarasCristina BirzuJérôme HonnoratBastien Joubert

Published in: Journal of neurology (2024)

Melanoma-associated PNS appear remarkably rare. The clinical similarities observed in neurological autoimmunity between ICI-treated and ICI-naïve patients, characterized predominantly by demyelinating polyradiculoneuropathy and myositis, suggest a potential prior immunization against melanoma antigens contributing to ICI-related neurotoxicity.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
prognostic factors
dendritic cells
blood brain barrier
patient reported