Bioactive compounds from Curcuma aeruginosa and the effect of comosone II on the migration and invasion of breast cancer cells.

Bioassay-guided separation afforded furanodienone 1,10-epoxide ( 9 ) as the new compound, curcolone ( 10) as partially described compound and ten known compounds; germacrone ( 1 ), furanodienone ( 2) , curzerenone (3 ), curcumenol ( 4 ), zederone ( 5 ), comosone II ( 6 ), (1E,4E,8R)-8-hydroxygermacra-1(10),4,7(11)-trieno-12,8-lactone ( 7 ), 13-hydroxygermacrone ( 8 ), curcuzederone ( 11 ) and demethoxycurcumin ( 12 ). The study showed that germacrone, furanodienone, curzerenone, comosone II, 13-hydroxygermacrone, curcuzederone and demethoxycurcumin are the bioactive compounds of C. aeruginosa rhizomes. Comosone II significantly inhibited MDA-MB-231 cell migration and invasion through the inhibition of MMP-9 enzyme. The present study may lead to further anticancer studies of comosone II and supports the traditional uses of C. aeruginosa rhizomes.