Does sex influence the natural history of idiopathic adult-onset dystonia?
Vittorio VelucciSarah IdrissiRoberta PellicciariMarcello EspositoAssunta TrinchilloDaniele BelvisiGiovanni FabbriniGina FerrazzanoCarmen TerranovaPaolo GirlandaGiovanni MajoranaVincenzo RizzoFrancesco BonoGiovanni IdoneVincenzo LaterzaLaura AvanzinoFrancesca Di BiasioRoberta MarcheseAnna CastagnaMarina RamellaChristian LettieriSara RinaldoMaria Concetta AltavistaLuigi PolidoriLaura BertolasiMaria Chiara TozziRoberto ErroPaolo BaronePierangelo BarberoRoberto CeravoloMarcello Mario MasciaTommaso ErcoliAntonella MuroniCarlo Alberto ArtusiMaurizio ZibettiCesa Lorella Maria ScaglioneAnna Rita BentivoglioMaria Sofia CotelliLuca MagistrelliGiovanni CossuAlberto AlbaneseGiovanna Maddalena SquintaniTommaso SchirinziAngelo Fabio GiganteLuca MadernaRoberto EleopraAntonio PisaniDaniela CassanoMarcello RomanoMarina RizzoAlfredo BerardelliGiovanni Defazionull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
Our findings provide novel evidence on sex as a key mediator of IAOD phenotype at disease onset. Age-related sexual dimorphism may result from the varying exposures to specific age-related and sex-related environmental risk factors interacting in a complex manner with biological factors such as hormonal sex factors.