Hemostatic Needles: Controlling Hemostasis Time by a Catecholamine Oxidative Pathway.
Mikyung ShinJae Hyuk ChoiKeumyeon KimSoomi KimHaeshin LeePublished in: ACS applied materials & interfaces (2021)
Most infectious human viruses are generally found in the bloodstream after being released by infected organs. Thus, hemorrhage in patients, whose blood contains infectious viruses might be a significant risk for secondary infections. In this work, a self-sealing hemostatic needle that causes no bleeding even after its removal is reported. The materials used for the self-sealing needles are inspired by mussel adhesive polysaccharide, chitosan-catechol, which shows a rapid phase transition from a solid phase (i.e., a thin film) to an adhesive gel upon coming into contact with blood. We found that the self-sealing time for the complete hemostasis depends on the oxidation pathway of the conjugated catechol. For high-temperature oxidation (i.e., 60 °C), Michael addition is a dominant oxidative coupling reaction, which weakens the chitosan-catechol attachment force on the needle surface. Thus, the film is easily transferred to the hemorrhaging sites, with the result that there is no bleeding even after a short injection time (<5 s). In contrast, during low-temperature oxidation (4 °C), Schiff base formation is dominant, which strengthens the film attachment force on the needle surface, resulting in continued bleeding owing to a dearth of tissue transfer after the injection.
Keyphrases
- ultrasound guided
- electron transfer
- hydrogen peroxide
- atrial fibrillation
- high temperature
- drug delivery
- room temperature
- end stage renal disease
- wound healing
- ejection fraction
- single molecule
- newly diagnosed
- endothelial cells
- hyaluronic acid
- prognostic factors
- peritoneal dialysis
- nitric oxide
- escherichia coli
- patient reported outcomes
- photodynamic therapy
- multidrug resistant
- magnetic resonance imaging
- computed tomography
- contrast enhanced
- genetic diversity
- gold nanoparticles