Diversity of RH and transfusion support in Brazilian sickle cell disease patients with unexplained Rh antibodies.

Carla Luana DinardoShannon KellyMarcia Regina DezanIngrid H RibeiroShirley L CastilhoLuciana C SchimidtMaria do C ValgueiroLiliana R PreissBrian CusterEster C SabinoConnie M Westhoffnull null

Published in: Transfusion (2019)

RHD variation in this SCD cohort differs from that reported for African Americans, with increased prevalence of RHD*DAR and underrepresentation of the DAU cluster. Many unexplained Rh antibodies were found in patients with conventional RH allele(s) only. RH genotyping was useful to guide transfusion to determine which patients could potentially benefit from receiving RH genotyped donor units.

Keyphrases

sickle cell disease
end stage renal disease
cardiac surgery
newly diagnosed
chronic kidney disease
prognostic factors
genome wide
peritoneal dialysis
dna methylation
patient reported outcomes
single cell