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Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b.

Caitlin BourkeEizo TakashimaLi-Jin ChanMelanie H DietrichRamin MazhariMichael WhiteJetsumon SattabongkotWai-Hong ThamTakafumi TsuboiIvo MuellerRhea J Longley
Published in: Malaria journal (2022)
To achieve P. vivax elimination goals, novel diagnostics are required to aid in detection of hidden parasite reservoirs. PvRBP2b was previously shown to be the top candidate for single-antigen classification of recent P. vivax exposure and here, it is concluded that several alternative recombinant PvRBP2b fragments can achieve equal sensitivity and specificity at predicting recent P. vivax exposure.
Keyphrases
  • plasmodium falciparum
  • binding protein
  • deep learning
  • loop mediated isothermal amplification
  • protein protein
  • amino acid
  • label free