Anti-GM-CSF Neutralizing Autoantibodies in Colombian Patients with Disseminated Cryptococcosis.

Carlos A Arango-FrancoMélanie MigaudIsabel Cristina Ramírez-SánchezKaren Arango-BustamanteMarcela Moncada-VélezJulián RojasAdrian GervaisSantiago Patiño-GiraldoLizeth J Perez-ZapataJesús A Álvarez ÁlvarezJulio César OrregoGustavo Roncancio-VillamilStéphanie Boisson-DupuisEmmanuelle JouanguyLaurent AbelJean-Laurent CasanovaJacinta BustamanteAndrés A AriasJosé Luis FrancoAnne Puel

Published in: Journal of clinical immunology (2023)

We report three Colombian patients with disseminated cryptococcosis associated with neutralizing auto-Abs against GM-CSF. Further studies should evaluate the genetic contribution to anti-GM-CSF autoantibody production and the role of the GM-CSF signaling pathway in the immune response to Cryptococcus spp.

Keyphrases

signaling pathway
cerebrospinal fluid
systemic lupus erythematosus
dengue virus
genome wide
epithelial mesenchymal transition
pi k akt
gene expression
dna methylation
oxidative stress
case control
aedes aegypti