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Confidence limits for the averted infections ratio estimated via the counterfactual placebo incidence rate.

David T DunnOliver T StirrupDavid V Glidden
Published in: Statistical communications in infectious diseases (2021)
The profile-likelihood method is preferred because of better coverage properties, but the simpler delta method is valid when the experimental treatment is no less effective than the control treatment. A complementary Bayesian approach, which can be applied when the counterfactual incidence rate can be represented as a prior distribution, is also outlined.
Keyphrases
  • risk factors
  • clinical trial
  • combination therapy
  • placebo controlled