Influence of Genetic and Epigenetic Factors of P2Y 12 Receptor on the Safety and Efficacy of Antiplatelet Drugs.

Dorota Danielak Kornel Pawlak Franciszek K Główka Marta Karaźniewicz-Łada

Published in: Cardiovascular drugs and therapy (2022)

genetic polymorphisms contribute to the effect exerted by other gene variants (such as CYP2C19*2/*3/*17), drug interactions, or patient habits, such as smoking. Also, epigenetic modifications, such as methylation or miRNA levels, may play a role in the efficacy of antiplatelet treatment.

Keyphrases

dna methylation
genome wide
copy number
gene expression
smoking cessation
combination therapy
replacement therapy