eIF3a-PPP2R5A-mediated ATM/ATR dephosphorylation is essential for irinotecan-induced DNA damage response.

Chao MeiZe-En SunLi-Ming TanJian-Ping GongXi LiZhao-Qian Liu

Published in: Cell proliferation (2022)

Our study suggested eIF3a with a high potential to influence phenotypic functions, which may contribute substantially to the early identification of susceptible individuals and the provision of personalized medication to irinotecan-treated patients.

Keyphrases

dna damage response
end stage renal disease
newly diagnosed
dna repair
ejection fraction
chronic kidney disease
healthcare
prognostic factors
high glucose
oxidative stress
human health
patient reported