Hypochlorous Acid Chemistry in Mammalian Cells-Influence on Infection and Role in Various Pathologies.
Celia María Curieses AndrésJosé Manuel Pérez de la LastraCelia Andrés JuanFrancisco J PlouEduardo Pérez-LebeñaPublished in: International journal of molecular sciences (2022)
This review discusses the formation of hypochlorous acid HOCl and the role of reactive chlorinated species (RCS), which are catalysed by the enzyme myeloperoxidase MPO, mainly located in leukocytes and which in turn contribute to cellular oxidative stress. The reactions of RCS with various organic molecules such as amines, amino acids, proteins, lipids, carbohydrates, nucleic acids, and DNA are described, and an attempt is made to explain the chemical mechanisms of the formation of the various chlorinated derivatives and the data available so far on the effects of MPO, RCS and halogenative stress. Their presence in numerous pathologies such as atherosclerosis, arthritis, neurological and renal diseases, diabetes, and obesity is reviewed and were found to be a feature of debilitating diseases.
Keyphrases
- fluorescent probe
- living cells
- type diabetes
- oxidative stress
- cardiovascular disease
- amino acid
- single molecule
- metabolic syndrome
- insulin resistance
- rheumatoid arthritis
- weight loss
- polycyclic aromatic hydrocarbons
- machine learning
- dna damage
- gas chromatography
- electronic health record
- circulating tumor
- weight gain
- big data
- high fat diet induced
- deep learning
- cell free
- induced apoptosis
- adipose tissue
- body mass index
- physical activity
- neural network
- skeletal muscle
- artificial intelligence
- nucleic acid
- data analysis
- heat shock protein