STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases.
Alex S FerecskóMiranda J SmallwoodAdrian MooreCorin LiddleJia NewcombeJanet HolleyJacqueline WhatmoreNicholas J GutowskiEdwin BremerPublished in: Biomedicines (2023)
The histological evidence shows that the common cGAS-STING pathway appears to be activated in endothelial and neural cells in all four neurodegenerative diseases examined. Together with the in vitro data, this suggests that the STING pathway might be activated via perturbation of mitochondrial stress and DNA leakage, resulting in downstream neuroinflammation; hence, this pathway may be a target for future STING therapeutics.
Keyphrases
- endothelial cells
- oxidative stress
- induced apoptosis
- traumatic brain injury
- lipopolysaccharide induced
- cell free
- circulating tumor
- small molecule
- cell death
- cell cycle arrest
- blood brain barrier
- electronic health record
- induced pluripotent stem cells
- endoplasmic reticulum stress
- brain injury
- lps induced
- data analysis
- inflammatory response
- subarachnoid hemorrhage