Immunomodulatory properties of captopril, an ACE inhibitor, on LPS-induced lung inflammation and fibrosis as well as oxidative stress.

Javad BoskabadiVahid Reza AskariMahmoud HosseiniMohammad Hossein Boskabady

Published in: Inflammopharmacology (2018)

Captopril dose dependently improved oxidant-antioxidant biomarkers, the imbalance between pro-inflammatory and anti-inflammatory cytokines and showed specific immunomodulatory effect on Th1/Th2 balance in the BALF of lung injury induced by LPS.

Keyphrases

oxidative stress
lps induced
inflammatory response
anti inflammatory
diabetic rats
dna damage
ischemia reperfusion injury
induced apoptosis
angiotensin ii
angiotensin converting enzyme
heat shock
signaling pathway