Biodegradable β-Cyclodextrin Conjugated Gelatin Methacryloyl Microneedle for Delivery of Water-Insoluble Drug.
Xingwu ZhouZhimin LuoAvijit BaidyaHan-Jun KimCanran WangXing JiangMoyuan QuJixiang ZhuLi RenFereshteh VajhadinPeyton TebonNiyuan ZhangYumeng XueYudi FengChengbin XueYi ChenKangJu LeeJunmin LeeShiming ZhangChun XuNureddin AshammakhiSamad AhadianMehmet Remzi DokmeciZhen GuWujin SunStefano PasseriniPublished in: Advanced healthcare materials (2020)
Transdermal delivery of water-insoluble drugs via hydrogel-based microneedle (MN) arrays is crucial for improving their therapeutic efficacies. However, direct loading of water-insoluble drug into hydrophilic matrices remains challenging. Here, a biodegradable MN array patch that is fabricated from naturally derived polymer conjugates of gelatin methacryloyl and β-cyclodextrin (GelMA-β-CD) is reported. When curcumin, an unstable and water-insoluble anticancer drug, is loaded as a model drug, its stability and solubility are improved due to the formation of an inclusion complex. The polymer-drug complex GelMA-β-CD/CUR can be formulated into MN arrays with sufficient mechanical strength for skin penetration and tunable drug release profile. Anticancer efficacy of released curcumin is observed in three-dimensional B16F10 melanoma models. The GelMA-β-CD/CUR MN exhibits relatively higher therapeutic efficacy through more localized and deeper penetrated manner compared with a control nontransdermal patch. In vivo studies also verify biocompatibility and degradability of the GelMA-β-CD MN arrays patch.
Keyphrases
- drug delivery
- drug release
- room temperature
- adverse drug
- cancer therapy
- high density
- drug induced
- water soluble
- metal organic framework
- emergency department
- transition metal
- tissue engineering
- nk cells
- hyaluronic acid
- high resolution
- high throughput
- soft tissue
- quantum dots
- simultaneous determination
- liquid chromatography