Imiquimod-Loaded Chitosan-Decorated Di-Block and Tri-Block Polymeric Nanoparticles Loaded In Situ Gel for the Management of Cervical Cancer.

Aliyah AlmomenMohamed M Badran Adel Ali AlhowyanMusaed AlkholiefAws Alshamsan

Published in: Gels (Basel, Switzerland) (2023)

IMQ and CS-IMQ NP in situ gels enhanced stability and drug release, and improved IMQ penetration through the vaginal tissues. Additionally, the new systems were able to increase the cytotoxic effect of IMQ against CC cells with a reduction in inflammatory responses. Thus, we believe that these systems could be a good alternative to commercial IMQ systems for the management of CC.

Keyphrases

drug delivery
drug release
cancer therapy
wound healing
induced apoptosis
cell cycle arrest
gene expression
oxidative stress
hyaluronic acid
endoplasmic reticulum stress
cell death
cystic fibrosis
pseudomonas aeruginosa
biofilm formation
reduced graphene oxide