Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats.

Filipe M O SilvaElerson C CostalongaCleonice SilvaAna C O CarreiraSamirah A GomesMari C SogayarCamilla FanelliIrene L Noronha

Published in: Molecular medicine (Cambridge, Mass.) (2019)

In conclusion, these findings indicate important roles of TGF-ß/Smad signaling in PF aggravated by uremia, providing data regarding potential therapeutic approaches with TAM or rBMP7 to block this process.

Keyphrases

transforming growth factor
oxidative stress
epithelial mesenchymal transition
electronic health record
bone mineral density
big data
liver fibrosis
estrogen receptor
binding protein
machine learning
amino acid
bone loss
body composition
artificial intelligence