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Catalyst- and solvent-free regioselective ring opening of aziridines with amines: application in the gram-scale synthesis of the α,β-diamino propionic derivative, aspergillomarasmine A.

Xing LinDajun ZhangJing LiLei Zhang
Published in: Organic & biomolecular chemistry (2023)
A green and efficient approach for synthesizing α,β-diamino propionic derivatives was developed through the ring opening of α- C -alkyloxycarbonyl aziridine. This method features catalyst- and solvent-free conditions, high regioselectivity, and wide substrate scope including solid amines, and realizes the gram-scale synthesis of aspergillomarasmine A.
Keyphrases
  • ionic liquid
  • gram negative
  • room temperature
  • reduced graphene oxide
  • highly efficient
  • carbon dioxide
  • multidrug resistant
  • visible light
  • amino acid