Prognostic value of FDG-PET indices for the assessment of histological response to neoadjuvant chemotherapy and outcome in pediatric patients with Ewing sarcoma and osteosarcoma.
Clement BaillyRodolphe LeforestierLoic CampionEstelle ThebaudAnne MoreauFrancoise Kraeber-BodereThomas CarlierCaroline Bodet-MilinPublished in: PloS one (2017)
Only elongation determined on initial FDG-PET has a potential interest as a prognostic factor of PFS and OS in pediatric OST patients. Unlike recent studies of the literature realized in adult population, all the metrics reveal limited additional prognostic value in pediatric EWS patients. This seems to reinforce the question of whether children experience different subtypes of the same pathologies than older patients, with different outcomes.
Keyphrases
- prognostic factors
- neoadjuvant chemotherapy
- end stage renal disease
- pet ct
- newly diagnosed
- chronic kidney disease
- ejection fraction
- positron emission tomography
- computed tomography
- metabolic syndrome
- squamous cell carcinoma
- adipose tissue
- dna methylation
- locally advanced
- patient reported outcomes
- physical activity
- climate change
- genome wide
- single cell
- community dwelling
- clinical evaluation
- case control