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Penetration of echinocandins into wound secretion of critically ill patients.

Tiziana GasperettiRené WelteHerbert OberacherJana MarxIngo LorenzPeter SchellongowskiThomas StaudingerKarin BurgmannPhilipp EllerTobias SantnerAndrea GriesmacherHartwig PfistererStephan EschertzhuberMaria AignerMichael JoannidisRomuald Bellmann
Published in: Infection (2021)
Echinocandin penetration into WS displays a high inter-individual variability. In WS of some of the patients, concentrations may be sub-therapeutic. However, the relevance of sub-therapeutic concentrations is unknown as no correlation has been established between concentration data and clinical outcome. Nevertheless, in the absence of clinical outcome studies, our data do not support the use of echinocandins at standard doses for the treatment of fungal wound infections, but underline the pivotal role of surgical debridement.
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