MEX3C-Mediated Decay of SOCS3 mRNA Promotes JAK2/STAT3 Signaling to Facilitate Metastasis in Hepatocellular Carcinoma.

Yunyun Xiao Yue Li Dongni Shi Xiaoqing Wang Shu-Qin Dai Muwen Yang Lingzhi Kong Boyu Chen Xinjian Huang Chuyong Lin Wen-Ting Liao Benke Xu Xin Chen Lishuai Wang Xiangfu Chen Ying Ouyang Guozhen Liu Heping Li Libing Song

Published in: Cancer research (2022)

This study reveals that RNA-binding protein MEX3C induces SOCS3 mRNA decay to promote JAK2/STAT3 activation and tumor metastasis in hepatocellular carcinoma, identifying MEX3C targeting as a potential approach for treating metastatic disease.

Keyphrases

binding protein
squamous cell carcinoma
cancer therapy
drug delivery
human health
climate change