Transcriptome and proteome mapping in the sheep atria reveal molecular featurets of atrial fibrillation progression.
Alba Alvarez-FrancoRaquel RoucoRafael J RamirezGuadalupe Guerrero-SernaMaria TianaSara CogliatiKuljeet KaurMohammed SaeedRicardo MagniJosé Antonio EnríquezFatima Sanchez-CaboJosé JalifeMiguel ManzanaresPublished in: Cardiovascular research (2022)
Transcriptomic and proteomic analysis of AF progression in a large animal model shows that significant changes occur at early stages, and that among others involve previously undescribed increase in mitochondria, changes to the chromatin of atrial CMs, and genes related to neural function and cell proliferation.
Keyphrases
- atrial fibrillation
- genome wide
- single cell
- cell proliferation
- left atrial
- catheter ablation
- rna seq
- dna methylation
- gene expression
- oral anticoagulants
- left atrial appendage
- direct oral anticoagulants
- heart failure
- high resolution
- transcription factor
- cell death
- cell cycle
- single molecule
- percutaneous coronary intervention
- reactive oxygen species
- high density
- endoplasmic reticulum
- signaling pathway
- mitral valve