A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.
Christopher G HubertShaun R StaufferJustin D LathiaPublished in: PLoS biology (2023)
Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.