Musculoskeletal complications following total body irradiation in hematopoietic stem cell transplant patients.
Taylor J JacksonSogol Mostoufi-MoabChristine E Hill-KayserNaomi J BalamuthAlexandre ArkaderPublished in: Pediatric blood & cancer (2017)
Total body irradiation (TBI) is commonly used in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) to treat benign and malignant disease. Though life-saving, these therapies place patients at risk for important side effects, including musculoskeletal complications such as short stature, osteonecrosis, slipped capital femoral epiphysis, and the development of benign and malignant bone tumors. With an increasing number of HSCT survivors, there is a growing need for awareness of the musculoskeletal complications of HSCT and TBI.
Keyphrases
- hematopoietic stem cell
- end stage renal disease
- allogeneic hematopoietic stem cell transplantation
- ejection fraction
- traumatic brain injury
- newly diagnosed
- chronic kidney disease
- prognostic factors
- acute myeloid leukemia
- risk factors
- peritoneal dialysis
- radiation therapy
- acute lymphoblastic leukemia
- bone mineral density
- body composition
- radiation induced