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Slowly Expanding Lesions Predict 9-Year Multiple Sclerosis Disease Progression.

Paolo PreziosaElisabetta PaganiAlessandro MeaniLucia MoiolaMariaemma RodegherMassimo FilippiMaria Assunta Rocca
Published in: Neurology(R) neuroimmunology & neuroinflammation (2022)
This study provides Class III evidence that in patients with RRMS starting treatment with natalizumab or fingolimod, the proportion of SELs on brain MRI was associated with EDSS score worsening and SPMS conversion at 9-year follow-up.
Keyphrases
  • multiple sclerosis
  • white matter
  • magnetic resonance imaging
  • contrast enhanced
  • resting state
  • magnetic resonance
  • diffusion weighted imaging
  • combination therapy
  • functional connectivity
  • blood brain barrier