Current use of autologous adipose tissue-derived stromal vascular fraction cells for orthopedic applications.
Jaewoo PakJung Hun LeeKwang Seung ParkMoonhee ParkLin-Woo KangSang-Hee LeePublished in: Journal of biomedical science (2017)
Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being tried in treating patients with osteoarthritis (OA), chondromalacia, meniscus tear, osteonecrosis of the femoral head, and tendon injuries. Here, we have reviewed available human clinical studies with regard to patient applications of autologous adipose SVF containing ASCs, specifically assessing effectiveness and safety in the field of orthopedic disorders. All studies reviewed in this article presents potential benefits of autologous adipose SVF in various orthopedic applications without any serious side effects.
Keyphrases
- adipose tissue
- bone marrow
- cell therapy
- insulin resistance
- stem cells
- platelet rich plasma
- endothelial cells
- high fat diet
- end stage renal disease
- induced pluripotent stem cells
- newly diagnosed
- ejection fraction
- mesenchymal stem cells
- rheumatoid arthritis
- type diabetes
- metabolic syndrome
- prognostic factors
- cell cycle arrest
- cell death
- anterior cruciate ligament reconstruction
- peritoneal dialysis
- soft tissue
- postmenopausal women
- patient reported outcomes
- extracellular matrix