Increased myocardial stiffness more than impaired relaxation function limits cardiac performance during exercise in heart failure with preserved ejection fraction: a virtual patient study.
Tim van LoonChristian KnackstedtRichard CornelussenKoen D ReesinkHans-Peter Brunner La RoccaTammo DelhaasVanessa van EmpelJoost LumensPublished in: European heart journal. Digital health (2020)
The CircAdapt model enabled realistic simulation of virtual HFpEF patients, covering a wide spectrum of LVDD and related limitations of cardiac exercise performance, all with preserved resting LVEF. Simulations suggest that increased LV passive stiffness, more than impaired relaxation function, reduces exercise tolerance, especially when LA function is impaired. In future studies, the CircAdapt model can serve as a valuable platform for patient-specific simulations to identify the disease substrate(s) underlying the individual HFpEF patient's cardiovascular phenotype.
Keyphrases
- high intensity
- left ventricular
- physical activity
- end stage renal disease
- case report
- ejection fraction
- resistance training
- molecular dynamics
- newly diagnosed
- chronic kidney disease
- heart rate
- prognostic factors
- high throughput
- single molecule
- current status
- atrial fibrillation
- patient reported
- virtual reality
- drug induced