Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction.

Ziyi SunZhangjun YunJianguo LinXiaoning SunQingqing WangJinlong DuanCheng LiXiaoxiao ZhangSiyu XuZeqi WangXingjiang XiongKui-Wu Yao

Published in: Journal of translational medicine (2024)

This study investigated the causal pathways associated with CHD and MI, highlighting the protective and risk roles of FES and PCSK9, respectively. FES. Specifically, the results showed that these proteins are promising therapeutic targets for future drug development.

Keyphrases

heart failure
mass spectrometry
left ventricular
current status
atomic force microscopy
label free