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An Efficient Suppression of EGFR and B-Raf mRNA Overexpression in the Lung of Benzo[a]pyrene-induced mice by Cationic Lipo-ATRA Nanoformulation.

Grace V M BerlinWilson D Davidnull SiddikuzamanViswanathan SR RagaviC GuruvayoorappanC Kathirvelan
Published in: Recent patents on nanotechnology (2023)
The study results have revealed the cationic lipo-ATRA treatment to have enhanced the bioavailability of ATRA in lung tissue due to its significant suppression action on EGFR-mediated oncogenes' expressions. Furthermore, the EGFR and BRaf could be the molecular targets of ATRA action in lung carcinogenesis.
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