Comparison of restorative proctocolectomy with and without defunctioning loop ileostomy in patients with ulcerative colitis - A systematic review and meta-analysis.

RPC without DLI is not associated with increased clinically overt AL or pouch excision rates, however, it is associated with increased risk of pelvic sepsis and emergency reoperation. RPC without DLI is feasible, but should only be performed judiciously in select UC patient cohorts in high volume, specialist, tertiary centres.