Login / Signup

Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses.

Daan F van den BergAna Rita CostaJelger Q EsserIlinka StanciuJasper Q GeisslerAdja Damba Zoumaro-DjayoonPieter-Jan HaasStan J J Brouns
Published in: Cell host & microbe (2024)
Prokaryotes have evolved a multitude of defense systems to protect against phage predation. Some of these resemble eukaryotic genes involved in antiviral responses. Here, we set out to systematically project the current knowledge of eukaryotic-like antiviral defense systems onto prokaryotic genomes, using Pseudomonas aeruginosa as a model organism. Searching for phage defense systems related to innate antiviral genes from vertebrates and plants, we uncovered over 450 candidates. We validated six of these phage defense systems, including factors preventing viral attachment, R-loop-acting enzymes, the inflammasome, ubiquitin pathway, and pathogen recognition signaling. Collectively, these defense systems support the concept of deep evolutionary links and shared antiviral mechanisms between prokaryotes and eukaryotes.
Keyphrases
  • pseudomonas aeruginosa
  • immune response
  • cystic fibrosis
  • innate immune
  • sars cov
  • genome wide
  • healthcare
  • transcription factor
  • small molecule
  • quality improvement
  • drug resistant
  • candida albicans