Excessive growth hormone promotes joint degeneration and chondrocyte metabolic dysfunction in mice.

Shouan ZhuHuanhuan LiuTrent DavisCraig R G WillisReetobrata BasuLuke WitzigreuterStephen BellNathaniel SzewczykMartin K LotzMarcheta HillRoberto J FajardoPatrick M O'ConnorDarlene E BerrymanJohn J Kopchick

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

These studies uncover that an excessive amount of GH promotes joint degeneration in mice, whereas antagonizing GH action through a GHa protects mice from OA development, which is associated with chondrocyte metabolic dysfunction and hypertrophic changes.

Keyphrases

growth hormone
high fat diet induced
oxidative stress
weight gain
type diabetes
insulin resistance
wild type
metabolic syndrome
knee osteoarthritis
body mass index
weight loss