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Highly E-Selective Synthesis of α-Fluoro-β-arylalkenyl Sulfones from gem-Difluoroalkenes with Sodium Sulfinates.

Yuxiu LiXiangqian LiXiaowei LiDayong Shi
Published in: The Journal of organic chemistry (2021)
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
Keyphrases
  • transition metal
  • positron emission tomography
  • computed tomography